Spring Arbor Living Blog

A new study in laboratory animals suggests a promising new avenue for treating Alzheimer's Disease. They were given a medicine that's been around for decades.
Immune globulin, or gamma globulin, is made from purified blood plasma and is normally used to boost the immune system.

Recently, scientists have been exploring its potential as a treatment for Alzheimer's Disease.

The results of these immune globulin experiments have been inconsistent. Researchers from the Mount Sinai School of Medicine in New York thought these inconsistent results were due to variations in how the immune globulin was administered. So they gave their lab mice very small doses intravenously over four weeks.

Researchers say they saw a dramatic slowdown in the animals' cognitive deterioration.

The treatment increases certain immune system components, which may help restore plasticity, the ability of the brain to rewire itself as needed. It may also have a role in reducing the beta amyloid protein deposits in the brain that are characteristic of Alzheimer's Disease.

The results of the study were presented at a scientific meeting called Experimental Biology 2012 in San Diego, California.

VOA News

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With the passage of time, most of us will notice changes in our memory or thinking. Forgetfulness is a normal part of getting older, but dementia  and Alzheimer's disease is not.

Yet, with good reason, we all worry.

Today, one in ten people 65 and older has Alzheimer's disease - about 5 million people. Yet only half of these people have actually been diagnosed with the disease. The rest don't even know they have it! And it's estimated that by 2050 as many as 16 million people will have Alzheimer's.

We read these statistics and wonder if and when it will it happen to me or someone in my family?"

If you're concerned because you've experienced recurring "senior moments". . . if you have any history of Alzheimer's or related memory disorders in your family. . . if a loved one has been showing signs of memory loss that concern you. . . if you are caring for someone recently diagnosed with Alzheimer's and are wondering about a new drug or therapy. . . it is critically important to learn everything you can about the disease so you can make informed decisions about getting the correct Alzheimer’s care, diagnosis and treatment. Partner with your doctor effectively, ask the right questions, and understand the answers.

For most people, Alzheimer's progresses very slowly. Deterioration of thinking, memory, and judgment are gradual. So you have time to learn about Alzheimer's, to make the best treatment choices, and to plan for the future.

Where Does Normal Forgetfulness End and Mild Cognitive Impairment Begin?

Some experts think that mild cognitive impairment (MCI) is the earliest manifestation of Alzheimer's. There is no definitive test for diagnosing Alzheimer’s - but clinical information from the patient's history and mental status exams are accurate about 90% of the time.

After screening for Alzheimer's, then what? Currently, there are 4 "symptomatic therapies" for Alzheimer's disease - drugs that can improve symptoms better than a placebo, but cannot cure patients or reverse the disease. Researchers estimate that only about 15% of Alzheimer’s patients actually take these medications.

Information from Johns Hopkins

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