Spring Arbor Living Blog

There is growing evidence between type II diabetes and the risk for Alzheimer’s disease. The evidence is even more pronounced now after a Japanese study. People with Diabetes are more than 35% more likely to develop Alzheimer's and those with the most severe diabetes have triple that risk.

There are some proteins that are controlled by insulin that also control the buildup of the material in the brain that causes Alzheimer’s disease.

Scientist at Mount Sinai School of Medicine found that insulin delivered directly to the brain with a special device through inhalation may treat Alzheimer’s, but it will take years for large studies to prove if this is an effective treatment. Type II diabetes affects millions of Americans.

Diet and Exercise are still the best answer at this point to preventing Type II diabetes, which directly relates to Alzheimer’s disease. The hope is that the link between diabetes and Alzheimer's will persuade Americans who were considering lifestyle changes to make those changes. Subscribe to the Spring Arbor Living Blog for regular information on Alzheimer's Disease, Treatment and Alzheimer's Care.

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A study published in Neurology has found that as problems not traditionally associated with brain health pile up, a person's chance of developing dementia increases.

As we age, those minor physical ailments – including sore feet, poorly fitting dentures and skin irritations – may turn out to be not so minor after all.

The 10-year study included more than 7,200 cognitively healthy 65-year-old Canadians who were asked questions about their health. The questions included known risk factors for Alzheimer's, such as high blood pressure and diabetes, they included 19 problems that seemingly have no connection with brain health – including vision and hearing, loose dentures, sinus congestion, arthritis, morning cough, and problems with the skin, stomach, kidneys or bowel.

Any healthy 65-year-old has an 18% chance of developing dementia in 10 years from aging, the study found that each health problem not traditionally associated with Alzheimer's increased that risk by 3.2%. The risk accelerated as more and more conditions were added, jumping to 40% among those in the study who reported as many as 12 conditions. Since age is a major risk factor for Alzheimer's, the study is in a sense identifying people who "age badly" - their biological age exceeds their chronological age.

Taking care of minor ailments improves a person's quality of life, no one has yet proved that fixing each problem would necessarily reduce the risk for Alzheimer's.

Walking as little as 30 minutes a day, three days a week decreases risk factors for dementia and improves overall health.

Original article AARP

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Dr. Potter, chief of the Division of Geriatrics and Gerontology at the University of Nebraska Medical Center says:

Stay mentally active. What actually happens is that as we get older, synapses in the brain are stimulated by mental activity, so this helps to preserve mental ability. Just being well-educated is a good idea. Education and mental stimulation helps to create and preserve and develop new connections. So taking a course later in life is a good idea.

Following a good heart-healthy diet is good for memory because what's good for your heart is good for your brain. And you can actually stimulate develop of new brain cells with physical activity.

Dr. Mastrianni, Associate Professor of Neurology; Co-Director, Center for Comprehensive Care and Research on Memory Disorders at the University of Chicago Medical Center says:

There things one can do to avoid developing Alzheimer's disease or memory decline associated with aging.  Lifestyle changes that have shown benefit include routine physical exercise, staying socially active and eating a heart-healthy diet. At least 30 minutes a day of physical activity gets your heart pumping and improves oxygenation of brain cells.

Social activity may include staying actively working, or volunteering in local organizations or clubs.  Research suggests that having a large network of social interactions helps to maintain good brain function and even delay Alzheimer's disease.

Finally, eliminating unhealthy practices such as cigarettes, too little sleep, and too much stress can't hurt and are likely to help your brain function better.

Dr. Shulman, assistant professor of neurology and associate director of Cognitive and Behavioral Neurology at the Pearl Barlow Center for Memory Evaluation and Treatment at the Silberstein Alzheimer's Institute at NYU Langone Medical Center says:

There are four main pillars of keeping healthy memory or maintaining brain fitness: healthy diet, exercise, keeping mentally stimulated and avoiding depression. There is no single entity that we can modify that will decrease the likelihood of someone developing Alzheimer's. It's a combination of applying all of these.

The issue with avoiding depression is a controversial one: Is depression itself a risk factor for dementia, or is the early sign of depression the earliest sign of dementia itself? It looks increasingly like it's a risk factor for Alzheimer's disease, and there's a whole host of complicated reasons, but it does seem that if you keep stress-free and depression-free, that in and of itself is insurance for healthy aging.

Original article My Health News Daily

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Carrying around extra pounds during middle age was associated with a higher risk of dementia later in life in a new study that followed twins in Sweden for 30 years.

The research was not set up to prove that dementia was caused by the added weight, but Dr. Weili Xu, the study's lead author, said that the evidence is pointing in that direction.

The findings suggest that "control of body fat as early as middle life is important to prevent dementia later in life," she told Reuters Health.

Xu and her colleagues analyzed data from close to 9,000 Swedish twins.

When the participants were an average age of 43, they gave researchers information about their height and weight.

Thirty years later, the researchers examined the same individuals for signs of declining thinking and memory skills, and then diagnosed some of them with Alzheimer's disease and other types of dementia.

Close to one in three of the participants were overweight or obese in middle age. And those that were had about an 80 percent higher chance of getting any kind of dementia than people of normal weight.

The more participants weighed in mid-life, the higher their chance of getting dementia or "questionable dementia" - meaning they had signs of thinking and reasoning problems, but not enough to be diagnosed with dementia.

In total, about 4 percent of everyone in the study was diagnosed with dementia, and another 1 to 2 percent with questionable dementia.

Despite the link between excess pounds in midlife and later dementia, when the researchers looked specifically at 137 twin pairs who were "discordant" - one twin had dementia and the other didn't - the tie to midlife overweight shrank considerably.

While Xu said that finding suggests that "there are some common genes that predispose (people) to both diseases (overweight and dementia)," it could also be that it was just more difficult to establish a solid link in such a small sample.

Whether genes predispose a person to being overweight in adulthood, or it's just bad eating habits, the likely explanation for the link to dementia is that fat tissue in the body releases hormones and other signaling cells that may affect the brain's functioning.

In addition, extra weight has been shown to increase a person's risk for diabetes and heart and blood vessel diseases - and those conditions are related to a higher dementia risk. However, the link between weight and dementia remained even after the researchers took other diseases into account.

The findings are the latest evidence that preventing Alzheimer's disease and dementia starts long before their signs and symptoms show up.

"People need to understand that what they do today could have an effect on them 30 or 40 years from now.”
When it comes to maintaining a healthy weight, what's good for the heart is good for the brain.

Original article - MSN

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Up to half of Alzheimer's disease cases worldwide are potentially attributable to seven preventable risk factors, a new study suggests. 

The findings show that Alzheimer's cases could be reduced if people quit smoking, increased their physical activity, enhanced their mental activity, controlled their blood pressure and diabetes, and managed their obesity and depression. 

The top 3 factors

In this study by University of California, San Fransisco, the authors reviewed previous research that examined factors that predispose people to developing Alzheimer's. They identified seven factors that were potentially within a person's control to change. 

Enhancing mental activity could make the biggest difference in developing Alzheimer's. That's because the study showed "low educational attainment" was the factor that impacts the largest portion of Alzheimer's cases worldwide. They defined low educational attainment as not completing higher education, having a low IQ or not participating in mentally stimulating leisure time activities, and found it contributes to 19% of Alzheimer's cases, or 6.5 million cases worldwide. 

Smoking contributes to the second-highest number of cases, 14% of cases, or 4.7 million cases worldwide.
Physical inactivity contributed to 13% of worldwide cases and was the third-largest factor. However, it was the highest contributor to cases in the U.S. — contributing to 21%, or 1.1 million cases. 

What really mattered was how common the risk factors were in the population. In the U.S., about a third of the population is sedentary, so a large number of Alzheimer's cases are potentially attributable to physical inactivity. 

However, worldwide, low education was more important, because so many people throughout the world are illiterate or are not educated beyond elementary school. And, smoking also contributed to a large percentage of cases worldwide because it is still very common. 

This suggests that smoking cessation and initiatives to increase physical activity could dramatically decrease  the number of Alzheimer's cases. 

A note of caution

It has been noted that while these seven factors may contribute to the development of Alzheimer's, none of the factors have been shown to cause the disease. 

However, the findings suggest "that preventive and therapeutic interventions have great potential," and that interventions should be carried out in high-risk populations. 

Globally, an estimated 33.9 million people have Alzheimer's, but that number could be reduced by 3 million if there was a 25% reduction in all seven of these risk factors. A 10% reduction in these seven factors could prevent 1.1 million cases. The number of worldwide cases is expected to triple over the next 40 years.

The results of the study were presented July 20 at The Alzheimer's Association 2011 International Conference on Alzheimer's Disease (ICAD), held in Paris. The study was simultaneously published online in the journal The Lancet Neurology. 

Original article on MSNBC.com

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