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A study published in Neurology has found that as problems not traditionally associated with brain health pile up, a person's chance of developing dementia increases.

As we age, those minor physical ailments – including sore feet, poorly fitting dentures and skin irritations – may turn out to be not so minor after all.

The 10-year study included more than 7,200 cognitively healthy 65-year-old Canadians who were asked questions about their health. The questions included known risk factors for Alzheimer's, such as high blood pressure and diabetes, they included 19 problems that seemingly have no connection with brain health – including vision and hearing, loose dentures, sinus congestion, arthritis, morning cough, and problems with the skin, stomach, kidneys or bowel.

Any healthy 65-year-old has an 18% chance of developing dementia in 10 years from aging, the study found that each health problem not traditionally associated with Alzheimer's increased that risk by 3.2%. The risk accelerated as more and more conditions were added, jumping to 40% among those in the study who reported as many as 12 conditions. Since age is a major risk factor for Alzheimer's, the study is in a sense identifying people who "age badly" - their biological age exceeds their chronological age.

Taking care of minor ailments improves a person's quality of life, no one has yet proved that fixing each problem would necessarily reduce the risk for Alzheimer's.

Walking as little as 30 minutes a day, three days a week decreases risk factors for dementia and improves overall health.

Original article AARP

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A unique treatment that uses insulin in the form of a nasal spray shows promise for boosting memory in men and women with Alzheimer's disease, according to a study released Sept. 12 in Neurology.

In a four-month study, participants with either mild or moderate Alzheimer's disease or mild cognitive impairment who received a low dose of insulin fared better on memory tests than those who received a placebo. Experts say that these encouraging results should lead to a larger clinical trial to confirm effectiveness of the treatment.

Insulin and Alzheimer's
Researchers selected 104 men and women for the study. All had mild to moderate Alzheimer's or mild cognitive impairment, a condition that increases the risk of developing Alzheimer's, especially when memory is affected.

The study found that men and women who used the insulin nasal spray tended to score better on memory tests than those who used the placebo. The group receiving insulin preserved their level of daily functioning, according to reports from their caregivers.
 
The brain needs insulin
Over the past 10 years scientists have come to learn that insulin plays an important role in the brain. It helps the brain form memories, allows brain cells to communicate with one another and manages levels of brain chemicals.

All cells, including brain cells, use glucose for energy. The hormone insulin makes it possible for glucose, aka blood sugar, to enter cells, enabling them to work properly. With age, however, many people develop a problem called insulin resistance, a condition in which the body and the brain do not use insulin effectively.

If glucose cannot enter brain cells, the cells won't carry out their tasks related to memory and thinking. "This sets the stage for problems in brain function that may develop into conditions like Alzheimer's disease," says Craft, lead author of the study. She and her colleagues set out to determine whether providing insulin directly to the brain could improve the cell's ability to use insulin.

Original article AARP

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Up to half of Alzheimer's disease cases worldwide are potentially attributable to seven preventable risk factors, a new study suggests. 

The findings show that Alzheimer's cases could be reduced if people quit smoking, increased their physical activity, enhanced their mental activity, controlled their blood pressure and diabetes, and managed their obesity and depression. 

The top 3 factors

In this study by University of California, San Fransisco, the authors reviewed previous research that examined factors that predispose people to developing Alzheimer's. They identified seven factors that were potentially within a person's control to change. 

Enhancing mental activity could make the biggest difference in developing Alzheimer's. That's because the study showed "low educational attainment" was the factor that impacts the largest portion of Alzheimer's cases worldwide. They defined low educational attainment as not completing higher education, having a low IQ or not participating in mentally stimulating leisure time activities, and found it contributes to 19% of Alzheimer's cases, or 6.5 million cases worldwide. 

Smoking contributes to the second-highest number of cases, 14% of cases, or 4.7 million cases worldwide.
Physical inactivity contributed to 13% of worldwide cases and was the third-largest factor. However, it was the highest contributor to cases in the U.S. — contributing to 21%, or 1.1 million cases. 

What really mattered was how common the risk factors were in the population. In the U.S., about a third of the population is sedentary, so a large number of Alzheimer's cases are potentially attributable to physical inactivity. 

However, worldwide, low education was more important, because so many people throughout the world are illiterate or are not educated beyond elementary school. And, smoking also contributed to a large percentage of cases worldwide because it is still very common. 

This suggests that smoking cessation and initiatives to increase physical activity could dramatically decrease  the number of Alzheimer's cases. 

A note of caution

It has been noted that while these seven factors may contribute to the development of Alzheimer's, none of the factors have been shown to cause the disease. 

However, the findings suggest "that preventive and therapeutic interventions have great potential," and that interventions should be carried out in high-risk populations. 

Globally, an estimated 33.9 million people have Alzheimer's, but that number could be reduced by 3 million if there was a 25% reduction in all seven of these risk factors. A 10% reduction in these seven factors could prevent 1.1 million cases. The number of worldwide cases is expected to triple over the next 40 years.

The results of the study were presented July 20 at The Alzheimer's Association 2011 International Conference on Alzheimer's Disease (ICAD), held in Paris. The study was simultaneously published online in the journal The Lancet Neurology. 

Original article on MSNBC.com

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One day your doctor might give you this prescription to prevent Alzheimer’s: Eat less red meat and sugar; eat more fruits, vegetables, fish and olive oil.

At least that seems to be the finding of a new study that found that eating a diet low in saturated fat and sugary treats can improve your memory and may reduce your risk of developing dementia.

Researchers with the University of Washington and Veterans Affairs Puget Sound medical center decided to see if a change in diet could affect the risk for Alzheimer’s or benefit those already suffering some mild but early symptoms of the disease.

What they found was that a diet rich in fruits, vegetables, grains, fish and olive oil can improve some memory skills in both healthy older adults, as well as those already experiencing cognitive difficulty.

More importantly, eating this kind of diet can help healthy adults reduce their risk of developing dementia, says study researcher Suzanne Craft with the Memory Wellness Program at the VA.

Researchers found that after four weeks on the low-fat diet, subjects had fewer toxic proteins and evidence of inflammation in their spinal fluid, both considered to be bio-markers for Alzheimer’s, Craft said.

“I like to think of this kind of diet as promoting healthy brain aging, as well as reducing the risk of Alzheimer’s,” she said.

The Washington state researchers wrote that they decided to take a “whole-diet” approach, rather than focus on a single dietary component, such as omega-3 fish oil. They also chose to test the subjects’ spinal fluid for bio-markers because of the importance of the central nervous system to brain health.

The 49 subjects, all older than 60, included 20 healthy adults with no signs of memory decline, and 29 who were at high-risk for Alzheimer’s, having already been diagnosed with some cognitive impairment.

They were randomly selected to either follow a four-week low-saturated fat, high-fiber plan similar to a Mediterranean diet, or a four-week high-saturated fat diet that included foods like red meat, butter, french fries and soda.

Both groups ate the same amount of protein and the diets were balanced so subjects did not lose or gain or weight.

However, for those who want to protect their brain health, it seems pretty clear from these preliminary results that eating a healthy diet is a powerful first step.

Original article on AARP

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The link to healthy diets and brain health is well established. The link to diet and Alzheimer's disease is less clearly established, but new information on curcumin (found in turmeric) may prove to be helpful.

The brain is particularly vulnerable to oxidative damage due to its high rate of metabolism and long-lived neurons. Free radicals can cause oxidative damage to important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if there is too much oxidative damage.

Antioxidants defend the cells from free radical damage. Many long term studies have demonstrated that those with higher antioxidants in their diets from fruits, vegetables and certain spices have slower rates of cognitive decline than those who ate less of these foods.

Curcumin has been studied recently because of the low rates of Alzheimer's disease in India. The Indian population consumes large amounts of curcumin through Tumeric and have a relatively low (4 times less) incidence of Alzheimer's disease compared to the U.S. population.

Curcumin is a member of the ginger family and is the main ingredient of turmeric, a spice used in curry and many Middle Eastern dishes. Curcumin is an antioxidant with nonsteroidal anti-inflammatory properties which prevents the damage caused by free radicals. The more antioxidants in the diet, the more the cells are protected.

The National Institutes of Health and other research organizations have been completing Alzheimer's clinical trials. Recently, curcumin has been in the forefront of much of this research. Curcumin's powerful anti-inflammatory and anti-oxidant properties suppress the buildup of beta-amyloid in brain tissue.

The National Institute of Neurological Disorders and Stroke (NINDS) studied mice and found that curcumin crosses the blood-brain barrier to bind with beta-amyloid peptides. These peptides are dangerous when they build up into plaques.

As Alzheimer's disease develops, neurons go through a process from a healthy state to some loss of molecular efficiency, to a loss of synaptic function, to loss of synapses, and, ultimately, to cell death. When curcumin was fed to aged mice, there was a reduction in amyloid levels and the overall amount of dangerous plaque.

More studies are needed to investigate the safety and tolerability of curcumin in the elderly population. Research is also needed in the areas of using curcumin to prevent Alzheimer's Disease as well as to lessen symptoms.

As clinical trials produce more information about the efficacy of curcumin, guidelines will be established for those at risk and for those affected.

Original article on CDApress.com by Seanne Safail, , Ph.D, RD

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In this excerpt from a recent issue of Health After 50, Marilyn Albert, Ph.D., director of the Johns Hopkins Alzheimer’s Disease Research Center, talks about current methods of diagnosing Alzheimer's Dementia.

•   Traditionally, how has Dementia been diagnosed? How accurately can it be diagnosed today?

Research now tells us that Dementia progresses over time and likely begins years or decades before symptoms first appear. But right now, we can only diagnose Dementia late in the game. 

To diagnose Dementia we rule out other potential causes for cognitive decline, such as stroke, tumor or metabolic syndrome (a combination of medical disorders that raises the risk of heart disease, diabetes and stroke that may also increase the risk of dementia).

We then run a battery of cognitive tests and brain scans to rule out other neurological disorders and to determine whether the pattern of symptoms seems consistent with Dementia. If these things match up, we can give a probable diagnosis of Dementia. At major medical centers, a probable Alzheimer's Dementia diagnosis can be 80 to 90 percent accurate.

•   What are biomarkers, and how will they help with earlier, more accurate diagnosis of Dementia?

"Biomarker" is a term that describes a measurable change in a person that will give us information about what is going on in his or her brain tissue. For example, the signature of Alzheimer’s disease includes amyloid plaques [abnormal accumulation of amyloid proteins] and neurofibrillary tangles (deposits of defective tau proteins, a type of protein abundant in the brain).

The proteins related to the plaques and tangles are present in the spinal fluid of patients with Dementia. They’re also present in those with mild cognitive impairment (MCI) -- slight problems in thinking, learning and remembering that sometimes progress to full-blown dementia.

The proteins serve as biomarkers of the progressive changes taking place in the brain. In clinical research, tau and amyloid have been shown to predict the progression of patients with MCI to Dementia and ultimately Alzheimer's.

In other words, measuring these proteins allows us to say more accurately and at an earlier stage of disease that we are pretty sure this person is going to develop Alzheimer’s dementia. Imaging procedures, such as PET (positron-emission tomography) and MRI (magnetic resonance imaging), also can provide information about the pathology present in the brain. For example, amyloid can now be measured with PET.

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Disease develops years before symptoms show.

New guidelines for diagnosing Alzheimer's disease set forth methods for identifying the disease before it progresses to full-blown dementia, and for the first time include lab and brain-imaging tests that can help identify Alzheimer's as the likely cause of a person's mental decline.

The guidelines, revised for the first time in 27 years, reflect a firm consensus among Alzheimer's researchers that the disease begins to attack the intricate structures of the brain 10 years or more before the disabling mental problems appear. Therefore, to be effective, drug or other therapies will have to begin work early in that process.

So far, though, there are no therapies that alter the course of Alzheimer's disease. And in a media briefing, authors of the new diagnosis guidelines emphasized that while testing for Alzheimer's pathology in the brain may one day be used to identify the disease at much earlier stages, today the tests are primarily a research tool. They are not ready for routine use in doctors' offices.

Delaying disability

Even so, doctors hope the new diagnostic criteria encourage people with worrisome memory problems to seek help. There's a lot patients and their families can do to minimize the impact of Alzheimer's, from structuring the patient's environment to optimizing medical care, activities, exercise and diet.

New tests outlined in the guidelines involve looking at the brain with imaging technologies and examining the fluid obtained by a spinal tap. The imaging studies can reveal so-called plaques made up of a protein called amyloid, a defining feature of Alzheimer's. They also can indicate characteristic patterns of shrinkage or reduced metabolic activity in the brain. The cerebrospinal fluid tests look for levels of amyloid as well as of another protein, tau, which makes up the twisted strands or "tangles" that, like plaques, are signature brain pathology in Alzheimer's.

Weaknesses of the tests

Research studies have demonstrated that all these tests can help identify Alzheimer's as the cause of a patient's dementia, and can help predict which patients with milder symptoms will go on to develop dementia. But the tests aren't conclusive in themselves. They aren't standardized so that a certain result means the same thing in every medical center. And there's no clear cutoff separating normal findings from those indicating a problem.

Original article by: Katharine Greider from AARP Bulletin

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Brain scans may help identify which individuals with a mild decline in their mental abilities will go on to develop Alzheimer's disease, according to a new study.
 
The research focused on patients with mild cognitive impairment, a condition in which people experience noticeable declines in their cognitive function, including memory and language problems. These changes are not severe enough to interfere with everyday activities, according to the Alzheimer's Association.
It is known that about 15 to 20 percent of such patients will go on to develop Alzheimer's, but researchers don't know which ones.

In the new study, which involved magnetic resonance imaging (MRI), researchers were able to identify a high-risk group – patients who had a 69 percent chance of developing Alzheimer's disease in the next year.

The study used the MRI scans to identify brain characteristics that put people at risk for Alzheimer's. The researchers determined some patients had just a 3 percent risk of developing Alzheimer's in the next year, which is about the same as for a healthy older person. Others had a 40 percent risk of developing the condition in the next year, or double the risk associated with a diagnosis of mild cognitive impairment, and still others were identified as part of the high-risk group, said study researcher Linda K. McEvoy, an assistant professor in the department of radiology at the University of California, San Diego School of Medicine.

A similar technique could be used one day by doctors to determine the Alzheimer's risk for patients with mild cognitive impairment. However, the patients in the study were not representative of the general population — they had been selected to exclude people who experienced other types of memory problems, such as those due to a stroke. A larger study would be needed before the results could be translated to the doctor's office.

Alzheimer's disease risk
The study looked at MRI scans of the brains of 203 healthy adults, 164 patients with Alzheimer's disease and 317 patients with mild cognitive impairment. Each patient had their brain scanned at the start of the study and again a year later.

The researchers first compared the brains of Alzheimer's disease patients with those of healthy people, looking for differences in the degree of  shrinkage, or atrophy, in particular areas of the brain. Once they developed a way to distinguish these two groups of people, "we could use the same equations on the mild cognitive impairment (MCI) subjects to determine their risk of developing Alzheimer's disease," McEvoy said.
 
When the researchers included information about how the brains had changed in the time between the two scans, they were able to identify the high-risk group.

Future applications
Information in this study will be critical once we have ways to prevent Alzheimer's disease, McEvoy said. "Currently there's no cure or prevention for Alzheimer's disease. But there's a lot of research going on right now into different potential therapies. If any of those therapies turn out to be useful, then this kind of information will be crucial — a doctor needs to know who's at higher risk in order to treat them".

 Original article by Rachael Rettner- MyHealthNewsDaily

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Have you ever walked into a room and then forgotten what you wanted once you got there? Have you ever put an item in a “safe place” and then forgot where it was when you needed it? Do you think sometimes that you are going “crazy” because you forget people’s names? Or maybe you forgot to do something you said you were going to do?

Sometimes we are having a “senior moment” as they say; but that’s just what it is–a moment. Usually the name is just on the tip of your tongue and you remember it when you can take the time to think. Or the reason for walking into the other room becomes clear when you slow down and let your thought catch up with you.  These are ”normal” occurrences usually due to stress, being too busy, not feeling well, or simply not paying attention.

However, when you misplace something and you have a problem retracing your steps to find it, this might be a warning sign.  If you are making a familiar recipe and forget how much salt to use, this could be normal.  But if you are confused about whether to use a measuring spoon or a measuring cup for the salt, this could be a warning sign.  If you drive to the mall and forget where you parked the car, this is typical of someone not paying attention or making a mental note of where they parked.  But, if you forget where you are and how you got there, this is a warning sign.

There are several warning signs to watch for in detecting early stage Alzheimer’s.  No one sign is an indication of having a problem in and of itself. Keeping track of abnormal behavior will give your physician details to help diagnose the problem, and only a qualified professional can make a diagnosis after appropriate testing. For more information on the warning signs, contact us today and we'll be happy to assist you in any way we can.

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In 2006, experts at Johns Hopkins University estimated that over 26 million people globally were living with Alzheimer’s disease. They also projected that instances of Alzheimer’s disease would increase globally to more than 106 million cases by the year 2050. By that time, 43% of Alzheimer’s patients will require high-level health care from highly skilled assisted living facilities. These troubling statistics were presented at conference for the prevention of dementia in Washington, D.C. on June 10.

The good news is that there is also growing body of evidence that suggests there are thing we can do to ward of the signs and symptoms of decline associated with Alzheimer’s disease and dementia. And it may be as simple as adding apple juice to our diets. Thomas B. Shea, PhD, and his team of researchers have conducted several laboratory studies which indicate that mice performed better than average in maze tests after drinking apple juice. It also seems to have prevented the normal decline in performance observed in the mice as they age.

In their most recent study, Shea and his colleagues found that mice who were giving the equivalent of 2 glasses of apple juice a day for an entire month produce less beta-amyloid, a protein fragment that is the cause of “senile plaques” that form in the brains of people who suffer from Alzheimer’s. The findings are significant because they suggest that something as simple as drinking apple juice routinely can improve brain function and possible delay key symptoms of Alzheimer’s disease.

The delayed onset of Alzheimer’s behaviors isn’t the only reason to drink apple juice. Here are some other benefits of drinking the beverage regularly:

• It contains nutrients and vitamins that may protect the body from other illnesses, like common colds.
• Apple juice also contains antioxidants, which are known to help prevent heart disease the development of some cancers.
• It can help reduce cholesterol.
• When consumed in moderation, it may also help promote weight loss.

Be sure to contact us should you have any questions about Alzheimer's or how we can provide custom care plans for individuals with this disease. We encourage you to seek out support as you take this journey and allow us to join you along the way.

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